Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid 99 fo100G
TRIFLUOROACETIC Trifluoroacetic acid 99 fo100G
Medchemexpress LLC YKL-5-124 trifluoroacetate | 2748220-93-9 | 99.7% | 629.63 | C30H34F3N7O5 | 10 MM x 1 ML
YKL-5-124 TFA is the trifluoroacetate salt of a potent, selective, irreversible, covalent cyclin-dependent kinase 7 (CDK7) inhibitor. Supplied as a 10 mM solution in DMSO (1 mL), it is intended for research use in biochemical and cellular assays and is reported to induce cell-cycle arrest and inhibit E2F-driven gene expression while minimally affecting RNA polymerase II phosphorylation.
- Potent, selective CDK7 inhibition
- Irreversible covalent mechanism of action
- Supplied as a 10 mM solution in DMSO, 1 mL vial
- High purity suitable for biochemical and cellular studies
- Molecular formula and mass provided for identification
Medchemexpress LLC QTX125 trifluoroacetate | 2989537-78-0 | 99.9% | 100 MG
QTX125 TFA is the trifluoroacetate salt of QTX125, a potent and highly selective histone deacetylase 6 (HDAC6) inhibitor with reported antitumor activity. Supplied as an off-white to gray solid for research use, it is available in multiple pack sizes and should be stored sealed and protected from moisture.
- Potent and selective HDAC6 inhibitor
- High reported purity and chemical stability
- Provided as a trifluoroacetate salt for improved handling
- Suitable for in vitro and preclinical research applications
- Store sealed, away from moisture; follow cold storage recommendations
Cambridge Isotope Laboratories Trifluoroacetic acid-D (D 99 5%) 10 x 0 5mL
Trifluoroacetic acid-D (D 99 5%) 10 x 0 5mL
TARGETMOL CHEMICALS INC GSMTX4 TFA 1209500-46-8 5MG
Also available in 1 mg 2 mg 10 mg and bulk. Please contact Fisher for quotes. GsMTx4 TFA (1209500-46-8 free base) (GsMTx4 TFA) is a spider venom peptide that selectively inhibits cationic permeable mechanically-sensitive channels (MSCs) belonging to the Piezo and TRP channel families.
Apexbio Technology LLC BIBP 3226 trifluoroacetate(Synonyms: BIBP3226 TFA, BIBP3226 trifluoroacetate salt, NPY Y1 receptor antagonist BIBP3226), 2mg, CAS: 1068148-47-9.
BIBP 3226 trifluoroacetate (CAS 1068148-47-9) is a non-peptide antagonist targeting neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptors showing binding affinity with Ki values of 1 1 nM (rNPY Y1) 79 nM (hNPFF2) and 108 nM (rNPFF) BIBP 3226 competes with NPFF prevents NPFF-induced inhibition of forskolin-stimulated cAMP production and blocks NPFF-dependent hypothermic and anti-opioid effects in rodent models This compound is employed experimentally to investigate NPY/NPFF system roles in anxiety analgesia and cardiovascular regulation
![Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000201969.png-250.jpg)
Medchemexpress LLC Carbamic acid, N-methyl-N-[2-(methylamino)ethyl] ester, 2,2,2-trifluoroacetate | 1224601-17-5 | MFCD01938808 | 98.1% | 620.57 g/mol | C29H31F3N4O8 | 1 ML
SN-38-CO-DMEDA TFA is a research-grade carbamate intermediate (trifluoroacetate salt) used in the synthesis of antibody-drug conjugates such as LND1035. Supplied as a 10 mM solution in DMSO (1 mL), it has CAS number 1224601-17-5, chemical formula C29H31F3N4O8, molecular weight 620.57 g/mol, and reported purity 98.07%.
- 10 mM solution in DMSO, 1 mL
- Intended for use as a chemical synthesis intermediate
- Reported purity 98.07%
- CAS number 1224601-17-5
- Available as solid quantities in multiple sizes