Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid Reage
TRIFLUOROACETIC Trifluoroacetic acid Reage
Medchemexpress LLC RSM3 TFA | 98.83% | 3049.66 | 5 MG
RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with a Kd of 3.10 μM. It inhibits tumor growth and induces cell apoptosis. RSM3 TFA can be used for the study of cancer.
- Inhibits tumor growth
- Induces cell apoptosis
- Used for the study of cancer
- Stapled peptide
- METTL3-METTL14 inhibitor
Medchemexpress LLC 5-FAM-LL-37 TFA | 95.76% | 4851.56 (free acid) | 1 MG
5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37, a LL-37 peptide labeled with fluorescein. It retains the antibacterial and immunomodulatory activities of LL-37 by binding to the bacterial cell membrane, thereby destroying its integrity and demonstrating broad-spectrum antibacterial efficacy.
- Retains antibacterial and immunomodulatory activities
- Binds to bacterial cell membrane
- Demonstrates broad-spectrum antibacterial efficacy
Medchemexpress LLC G-Pen-GRGDSPCA (TFA) | 98.8% | 948.04 | 5 MG
G-Pen-GRGDSPCA (TFA) is a solid, white to off-white chemical product primarily identified for use as a laboratory chemical and in the manufacture of substances. It demonstrates stability under recommended storage conditions.
- Appearance: white to off-white solid
- Chemical stability: stable under recommended storage conditions
- Identified uses: laboratory chemicals, manufacture of substances
- Purity: 98.76% (LCMS)
- Consistent with structure (LCMS)
Medchemexpress LLC RVG TFA | 99.3% | 3266.62 | 5 MG
RVG TFA is a peptide derived from Rabies Virus Glycoprotein. It binds to the α-7 subunit of nicotinic acetylcholine receptors (AchR) of neuronal cells and enhances the delivery of *Mycobacterium tuberculosis* antigens to antigen-presenting cells.
- Binds to α-7 subunit of nicotinic acetylcholine receptors
- Enhances delivery of *Mycobacterium tuberculosis* antigens
- Appears as a solid
- Color: white to off-white
- Soluble in water at ≥ 100 mg/mL
- For research use only
Medchemexpress LLC KS-133 (TFA) | 98.95% | 1672.93 | 1 MG
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2). It reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. It is suitable for research on schizophrenia and cancer immune regulation.
- Highly selective and potent VIPR2 antagonist
- IC50 values for Ca influx measurement: 24.8 nM; cAMP measurement: 500 nM
- Reverses M2 to M1 macrophage phenotype
- Alters tumor immune microenvironment and inhibits tumor growth
- Inhibits excessive VIPR2 activation, preventing cognitive impairments and neuronal damage
- Demonstrates anti-tumor activity and synergistic effects with anti-PD-1 antibodies
Medchemexpress LLC Gmprga Tfa | 98.1% | 5 MG
GMPRGA TFA is the trifluoroacetic acid (TFA) salt form of GMPRGA. It is known to recognize spAimR in the bacterial cytosol, a process that induces lysogeny.
- TFA salt form
- Recognizes spAimR in bacterial cytosol
- Induces lysogeny
- Functions as an inhibitor
- Part of bacterial lysis-lysogeny studies
- Classified as an antimicrobial peptide
Medchemexpress LLC Mal-PEG4-C2-NH2 TFA | 2512227-13-1 | 98.6% | 430.37 | 500 MG
Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
Medchemexpress LLC Mazdutide TFA | 2259884-03-0 | 99.7% | 4563.06 | 1 MG
Mazdutide TFA is a long-acting synthetic oxyntomodulin analog. It acts as a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). It stimulates insulin secretion from mouse islets and is utilized in studies for obesity and type 2 diabetes (T2D).
- Acts as a co-agonist of GLP-1R and GCGR
- Stimulates insulin secretion from mouse islets
- Used in studies of obesity and type 2 diabetes
- Reduces body weight and physical intake in diabetic mice with diet-induced obesity
Medchemexpress LLC VU0364572 (TFA) | 1240514-89-9 | 99.3% | 487.51 | 25 MG
VU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. It demonstrates neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's Disease and is CNS penetrant.
- Orally active and selective allosteric agonist of the M1 muscarinic receptor.
- Neuroprotective potential for preventing memory impairments.
- Reduces neuropathology in Alzheimer's Disease.
- CNS penetrant.
Medchemexpress LLC Ac-devd-cmk tfa | 98.6% | 664.97 | 5 MG
Ac-DEVD-CMK TFA is a selective and irreversible caspase-3 inhibitor. It significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate, and can be used in various experimental approaches to inhibit apoptosis.
- Selective and irreversible caspase-3 inhibitor.
- Significantly inhibits apoptosis induced by high levels of glucose or 3,20-dibenzoate.
- Suitable for various experimental approaches to inhibit apoptosis.
- Inhibits IDB-induced apoptosis.
- Attenuates acetaminophen-induced liver injury.
- Mitigates liver damage by inhibiting GSK‐3β or caspase‐3 activity.
- Effective in inhibiting citrate-induced p21 cleavage and G2/M accumulation in human pharyngeal squamous carcinoma cell lines.
Medchemexpress LLC Gastric inhibitory peptide (GIP), human (TFA) | 98.5% | 4983.53 | 5 MG
Gastric inhibitory peptide (GIP), human (TFA) | 98.5% | 4983.53 | 5 MG
Apexbio Technology LLC Pyrophosphatase Inorganic (E. coli) 10 units
Pyrophosphatase Inorganic (E coli) purified from recombinant E coli strain carrying the E coli inorganic pyrophosphatase gene Inorganic pyrophosphatase (PPase) is a ubiquitous enzyme that catalyzes the hydrolysis of inorganic pyrophosphate into orthophosphate
Proteochem Inc TFA Ampules (Proteomics Grade), 76-05-1, MFCD00004169, 10 amps
MF: C2 H F3 O2, MW: 114.03, Alternative Names: TFA Ampoules; Trifluoroacetic Acid Ampoules; TFA Amps. Trifluoroacetic acid (TFA) is an effective ion pairing agent for HPLC and proteomics LCMS applications which are regularly used to resolve chromatographically similar analytes.