Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC D-GsMTx4 TFA | 99.9% | 4095.84 | 100 UG
D-GsMTx4 TFA is a spider peptide and the D enantiomer of GsMTx4. It inhibits the mechanosensitive ion channel Piezo2, [Ca2+]i elevation, and mTOR and PI3K-Akt signaling pathways. This compound can inhibit mechanical allodynia and thermal hyperalgesia.
- Inhibits the mechanosensitive ion channel Piezo2.
- Inhibits intracellular calcium elevation.
- Inhibits mTOR and PI3K-Akt signaling pathways.
- Can be used in research related to mechanical stress.
- Useful for studies on chronic pain and idiopathic pulmonary fibrosis.
Medchemexpress LLC F9170 (TFA) | >98% | 2097.33 | 1 MG
F9170 (trifluoroacetate salt) is an antiviral peptide that corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein. This product is identified as a laboratory chemical for the manufacture of substances and is strictly for research use only. It must be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- Antiviral peptide.
- Corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein.
- Intended for research use only.
- Suitable for laboratory chemical applications.
- Recommended for handling by experienced personnel.
Medchemexpress LLC Siivfekl (Tfa) | 99.85% | 948.16 | 1 MG
SIIVFEKL TFA is an antigenic peptide, a variant of the major MHC class I-restricted epitope SIINFEKL. It is designed to stimulate specific T cells in experimental settings to study the competitive interaction between T cells. This peptide exhibits low affinity for the OT-I T cell receptor (TCR) and is suitable for the detection of CD8+ T cells.
- Variant of the major MHC class I-restricted epitope SIINFEKL
- Stimulates specific T cells for competitive interaction studies
- Exhibits low affinity for the OT-I T cell receptor (TCR)
- Suitable for detection of CD8+ T cells
- High purity of 99.85%
- Provided as a white to off-white solid
- Stable under recommended storage conditions
Medchemexpress LLC Clovibactin TFA | 97.1% | 903.08 | 100 UG
Clovibactin TFA is the TFA salt form of Clovibactin. It is an antibiotic effective against drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inhibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors.
- Effective against drug-resistant bacterial pathogens
- Exhibits no detectable resistance
- Inhibits cell wall synthesis
- Targets pyrophosphate of peptidoglycan precursors
Medchemexpress LLC Gln-AMS TFA | 99.9% | 588.47 | 100 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor, specifically inhibiting glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM.
- Inhibits glutaminyl-tRNA synthetase (GlnRS)
- Type Ia aminoacyl-tRNA synthetase (AARS) inhibitor
- White to off-white solid
- Purity of 99.85%
- Soluble in DMSO at 100 mg/mL
- Store at -20°C under nitrogen
Medchemexpress LLC DEC-RVRK-CMK TFA | 96.1% | 744.41 | 1 MG
DEC-RVRK-CMK (Decanoyl-Arg-Val-Arg-Lys-chloromethylketone) TFA is a peptide-based CMK (chloromethylketone) inhibitor that targets and inactivates the secreted soluble kexin (Kex2) (Ki=8.45 μM). The yeast enzyme Kex2 (kexin, EC 3.4.21.61) is a calcium-dependent transmembrane protease and belongs to the mammalian protease family of the serine protease subtilisin family. The binding mechanism of Kex2 with different CMK inhibitors depends on substrate selectivity, particularly the selective differences between lysine and arginine at the P1 position. It is for research use only.
- Peptide-based CMK inhibitor
- Targets and inactivates secreted soluble kexin (Kex2)
- Ki of 8.45 μM against ssKex2
- Inhibits yeast enzyme Kex2 (kexin, EC 3.4.21.61)
- Calcium-dependent transmembrane protease
- Useful for studying binding mechanisms and substrate selectivity
Medchemexpress LLC GIP, rat TFA | 99.8% | 5002.58 | 5 MG
GIP, rat TFA is a bioactive peptide of rat origin, also known as glucose-dependent insulinotropic polypeptide or gastric inhibitory polypeptide. This 42-amino acid peptide is released by K cells in the duodenum and jejunum in response to food intake. GIP, along with GLP, stimulates insulin secretion from pancreatic beta cells and appears to promote beta cell proliferation and survival. Recent studies suggest a role for GIP in lipid homeostasis and a potential function in the pathogenesis of obesity.
- Bioactive peptide of rat origin
- 42-amino acid peptide
- Released by K cells in duodenum and jejunum
- Stimulates insulin secretion from pancreatic beta cells
- Promotes beta cell proliferation and survival
- Plays a role in lipid homeostasis
Medchemexpress LLC KRpep-2d TFA | 2098181-84-9 | 95.09% | 2675.03 | 25 MG
KRpep-2d TFA is a potent K-Ras inhibitor that inhibits the proliferation of K-Ras-driven cancer cells. It possesses a cyclic structure, with specific amino acid residues (Leu77, Ile9, and Asp12) being critical for its K-Ras inhibitory activity. This peptide can be used for cancer research.
- Potent K-Ras inhibitor
- Inhibits proliferation of K-Ras-driven cancer cells
- Cyclic structure important for inhibitory activity
- Demonstrates inhibitory activity in A427 cells
- Targets Ras
- Involved in GPCR/G Protein and MAPK/ERK Pathway
Medchemexpress LLC Pam3CSK4 (TFA) | 112208-01-2 | 99.9% | 1852.30 | 25 MG
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist, demonstrating an EC50 of 0.47 ng/mL for human TLR1/2. This compound is a TLR1/2 heterodimer that specifically recognizes triacylated lipopeptides. It has been shown to enhance the antibacterial functions of granulocyte macrophage-colony stimulating factor (GM-CSF) induced neutrophils against Methicillin-resistant Staphylococcus aureus (MRSA).
- Acts as a TLR1/2 agonist
- Effective at an EC50 of 0.47 ng/mL for human TLR1/2
- Recognizes triacylated lipopeptides
- Enhances antibacterial functions of GM-CSF induced neutrophils
- For research use only
- Appears as a white to off-white solid
Medchemexpress LLC 5A2-SC8 TFA | 1857341-90-2 | 98.6% | C93H173N5O20S5.xC2HF3O2 | 1 MG
5A2-SC8 TFA is an ionizable amino lipid utilized in lipid nanoparticles (LNPs), demonstrating significant potential for drug delivery with low in vivo toxicity. It facilitates the efficient delivery of small RNAs, such as siRNA and miRNA, specifically into tumor cells. This compound's LNPs can uniquely influence the delivery fate of RNA within the liver, thereby improving therapeutic outcomes in various cancer models.
- High delivery potential.
- Low in vivo toxicity.
- Enables efficient delivery of small RNAs (siRNA and miRNA) into tumor cells.
- Can alter therapeutic outcomes in cancer models by influencing RNA delivery in the liver.
Medchemexpress LLC Wrwyar-NH2 TFA | 70.8% | 936.07 | 5 MG
Wrwyar-NH2 TFA is a control peptide primarily targeting DNA/RNA synthesis. It plays a role in the Cell Cycle/DNA Damage pathway. This product is intended for research use only and has not been fully validated for medical applications.
- Control peptide
- Targets DNA/RNA synthesis
- Involved in cell cycle/DNA damage pathway
- For research use only
Medchemexpress LLC (RXR)4XB TFA | 96.6% | 5 MG
(RXR)4XB TFA is a cell-penetrating peptide that binds phosphorodiamidate morpholino oligomers (PMOs), forming peptide-conjugated PMOs (PPMOs). It improves the delivery of PMO into bacterial cells.
- Prevents biofilm formation
- Inhibits *Pseudomonas aeruginosa* with an MIC50 of 0.5 to 16 μM
- Reduces bacterial burden in mouse acute pneumonia models
Medchemexpress LLC Hr97 Tfa | 1518.84 | 1 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops called HR97-SunitiGel. The peptide-drug conjugate can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Combines with engineered melanin to prepare eye drops
- Supports sustained ocular drug delivery
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Shortened sequence: FSGKRRKRKPRC
- In vitro solubility: 50 mg/mL in DMSO (need ultrasonic)
Medchemexpress LLC NLS-StAx-h TFA | 98.9% | 3559.28 | 1 MG
NLS-StAx-h TFA is a selective, cell permeable, stapled peptide that inhibits Wnt signaling, with an IC50 of 1.4 μM. It effectively inhibits interactions between β-catenin and transcription factors and demonstrates anti-proliferative effects on cancer cells, including SW-480 and DLD-1 colorectal cancer cells.
- Selective, cell permeable, stapled peptide
- Inhibits Wnt signaling with an IC50 of 1.4 μM
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation of cancer cells
- Inhibits proliferation of colorectal cancer cells (SW-480 and DLD-1 cells) by more than 80% at 10 μM
- Inhibits migration of DLD-1 colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC AH-D peptide TFA | 98.8% | 3283.75 | 5 MG
AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy.
- Antiviral peptide
- Disrupts membrane structures within exosome size range
- Induces T-EXO depletion
- Enhances cancer immunotherapy
- Solid, white to off-white appearance
- Store sealed, away from moisture
- Powder storage at -80°C for 2 years, -20°C for 1 year
- In solvent storage at -80°C for 6 months, -20°C for 1 month