Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC TAM557 TFA | 98.5% | 1119.34 | 1 MG
TAM557 TFA is a cytotoxic tubulysin compound designed for conjugation to transport vehicles such as proteins, peptides, small molecules, or polymeric carriers that incorporate a targeting principle. It is intended for research use only.
- Cytotoxic tubulysin compound
- Modified for conjugation to transport vehicles
- Appearance: solid, white to off-white
- Shipping at room temperature
- Store at -20°C, sealed, away from moisture and light
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Peptide R TFA | 98.3% | 900.08 | 5 MG
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It exhibits outstanding capacities to remodel the tumor stroma and can be used for solid tumor research, including glioblastoma.
- Synthetic and specific CXCR4 antagonist
- Exhibits outstanding capacities to remodel the tumor stroma
- Can be used for solid tumor research, including glioblastoma
- Molecular weight is 900.08 (free base)
- Appears as a white to off-white solid
- Sequence is Arg-Ala-Cys-Arg-Phe-Phe-Cys with a disulfide bridge at Cys3-Cys7
Medchemexpress LLC Cpn-267 tfa | 1279.27 | 1 MG
Cpn-267 tfa is a selective agonist for neuromedin U receptor 1 (NMUR1) with an EC50 of 0.25 nM. This compound has been shown to suppress body weight gain in mice, suggesting its potential use in the study of obesity. It is provided as a solid for research applications.
- Selective NMUR1 agonist.
- Potent activity at nanomolar concentrations.
- Demonstrated suppression of body weight gain in animal models.
- Suitable for obesity research.
Medchemexpress LLC 2-Furancarboxamide, 5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl] | C25H20F3N5O6 | 5 MG
W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. It inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. W1131 effectively alleviates cancer cell chemoresistance to 5-FU, and regulates the cell cycle, DNA damage response, and oxidative phosphorylation, including the IL6-JAK-STAT3 pathway and the ferroptosis pathway.
- Potent STAT3 inhibitor
- Induces ferroptosis
- Inhibits cancer progression in gastric cancer models
- Alleviates cancer cell chemoresistance to 5-FU
- Regulates cell cycle and DNA damage response
- Regulates oxidative phosphorylation
- Regulates IL6-JAK-STAT3 pathway
- Regulates ferroptosis pathway
Medchemexpress LLC Ala-MPSD TFA | 136561-67-6 | 98.02% | 3016.76 (free base) | 1 MG
Ala-MPSD TFA is a control peptide for MPSD. In this peptide, the four serine residues of MPSD are substituted by alanines. This product is intended for research use only.
- Control peptide for MPSD
- Four serine residues substituted by alanines
- For research use only
Medchemexpress LLC Caloxin 2A1 TFA | 99.9% | 1592.54 | 25 MG
Caloxin 2A1 TFA is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. It does not affect basal Mg2+-ATPase or Na+-K+-ATPase.
- Extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor.
- Does not affect basal Mg2+-ATPase or Na+-K+-ATPase.
- Inhibits Ca2+-Mg2+-ATPase in human erythrocyte leaky ghosts.
- Inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate.
- Increases airway smooth muscle cells (ASMCs) apoptosis.
Medchemexpress LLC SAIRGA (TFA) | 99.6% | 573.64 | 1 MG
SAIRGA (TFA) is a chemical derived from the phages phi3T, capable of recognizing phAimR in the bacterial cytosol to induce lysogeny. This product is suitable for use as a laboratory chemical in the manufacture of various substances.
- Solid appearance
- Has a purity of 99.6%
- Features a molecular weight of 573.64
- Stable under recommended storage conditions
- Suitable for research applications only
- Store at -80°C for up to 2 years or -20°C for up to 1 year (powder, sealed storage, away from moisture and light)
Medchemexpress LLC Maurocalcine TFA | 269745-22-4 | 95.09% | 3858.55 (free base) | 1 MG
Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2, and 3 with cellular permeability. It induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM and exhibits an apparent affinity of 14 nM for RyR2. This compound can be applied to in vivo cell tracking or other cell imaging techniques. Maurocalcine (100 nM, 24 h) increases the sensitivity of RyR2 to activating [Ca2+]i and decreases its sensitivity to inhibiting [Ca2+]i. Maurocalcine (5 μM, 4 h/24 h) shows no significant cell toxicity for HEK293.
- Agonist of ryanodine receptor (RyR) channel types 1, 2 and 3.
- Possesses cellular permeability.
- Induces [3H]ryanodine binding on RyR1.
- Exhibits affinity for RyR2.
- Can be used for in vivo cell tracking or cell imaging techniques.
Medchemexpress LLC Homoglutathione TFA | 95.0% | 435.37 | C13H20F3N3O8S | 5mg
Homoglutathione (TFA) is a biological molecule
Medchemexpress LLC Huwentoxin-IV TFA | 526224-73-7 | 4106.78 | 100 UG
Huwentoxin-IV is a potent and selective sodium channel blocker that inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4. It preferentially blocks the peripheral nerve subtype Nav1.7 by binding to neurotoxin receptor site 4. This compound has demonstrated analgesic effects in animal models of inflammatory and neuropathic pain. Its molecular weight is 4106.78, with a chemical formula of C174H278N52O51S6.
- Inhibits Nav1.7 with an IC50 of 26 nM
- Inhibits Nav1.2 with an IC50 of 150 nM
- Inhibits Nav1.3 with an IC50 of 338 nM
- Inhibits Nav1.4 with an IC50 of 400 nM
- Features sequence: Glu-Cys-Leu-Glu-Ile-Phe-Lys-Ala-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ss-Lys-Leu-Val-Cys-Ser-Arg-Lys-Thr-Trp-Cys-Lys-Tyr-Gln-Ile-NH2
- Includes disulfide bridges: Cys2-Cys17; Cys9-Cys24; Cys16-Cys31
Medchemexpress LLC Ebiratide TFA | 99.0% | 996.23 | 5 MG
Ebiratide TFA (HOE-427) is an ACTH 4-9 derivative that acts directly on the central nervous system and shows memory-enhancing effects. It increases acetylcholine (ACh) metabolism in the rat brain. Ebiratide TFA has neuroprotective efficacy in mice models with electroconvulsive shock and Scopolamine-induced memory impairment, demonstrating anti-amnestic efficacy.
- ACTH 4-9 derivative.
- Acts directly on the central nervous system.
- Exhibits memory-enhancing efficacy.
- Enhances acetylcholine (ACh) metabolism in rat brain.
- Exhibits neuroprotective and anti-amnestic efficacy in animal models.